1 Feline Infectious Peritonitis and Coronavirus Website, 64470 Etchebar, Pyrenees, France

2 Independent Researcher, Maidstone ME14 5BF, Kent, UK

3 School of Veterinary Medicine, University of Glasgow, Garscube Campus, Bearsden Road, Glasgow G61 1QH, UK

4 Newnham Court Veterinary Hospital, Bearsted Road, Weavering, Maidstone ME14 5E, Kent, UK

*Author to whom correspondence should be addressed.

Viruses 2020, 12(11), 1216; https://doi.org/10.3390/v12111216

Received: 29 August 2020 / Revised: 3 October 2020 / Accepted: 5 October 2020 / Published: 27 October 2020

1. Introduction

Feline coronavirus (FCoV) is a highly infectious enteric virus which causes subclinical infection or diarrhoea in the majority of infected cats [1], but potentially lethal monocyte-associated immune-mediated granulomatous vasculitis [2], known as feline infectious peritonitis (FIP), in around 10% of infected cats [1]. FCoV is a positive-sense RNA alpha coronavirus, and a member of the Coronaviridae family of the order Nidovirales[3].

Although FIP treatment with an injectable nucleoside analogue [4] and cure of enteric FCoV infection with an oral adenosine nucleoside analogue (Mutian, Nantong Biotechnology, China) have previously been reported [5], this case report the first description of the recovery of a cat with a systemic FCoV infection i.e., FIP using Mutian.

4. Conclusions

To our knowledge, this is the first published case of an oral adenosine nucleoside analogue followed by recombinant feline interferon being used to cure a cat of non-effusive FIP, and of AGP being used as a marker of recovery from FIP. We recommend SAMe supplementation be given along with Mutian to protect the liver, and monitor liver enzyme levels. SDMA levels in future cases following this FIP treatment protocol require further investigation. We suggest that systemic corticosteroids are contraindicated in FIP treatment other than for palliative purposes.

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